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FROM:  Dr. Linda Munson/ Dr. Anneke Moresco

      Pathology and Veterinary Advisors for AZA Contraceptive Advisory Group

      University of California- Davis

      Dept. VM-PMI

      4206 VM3A

      1 Shields Avenue

      Davis, California 95616

      Phone: 530-754-7963, FAX: 530-752-3349, Email: 

DATE:  May 29, 2007 

SUBJECT: Update on Contraceptive Health Surveillance Center 

      The AZA Contraceptive Advisory Group is continuing the pathology surveillance of reproductive tracts from captive and free-ranging female animals to determine if there are adverse reactions to contraceptives.  For this surveillance, we need the reproductive tracts from all female mammals regardless of their contraceptive history so we can compare normal aging changes with lesions arising from contraceptive use. We are also examining reproductive tracts from any contracepted male mammals (regardless of the method).   

SAMPLES to submit: Females: Intact, formalin-fixed reproductive tracts (uterus, ovaries and mammary gland if possible) obtained from necropsy or ovariohysterectomy of any female mammal. Males: Half of each testis (include cauda and head of epididymis) obtained at necropsy or castration. 

FIXATION: Make a small incision into the body of the uterus (for primates) or into each horn (for species with bicornuate uteri). For testes, send half of each testis, cut longitudinally. Immerse tissues in buffered formalin for at least 72 hours (ratio of tissue to formalin = 1:10).   

SHIPPING: Wrap fixed tracts in formalin-soaked paper towels, enclose in a leak-proof plastic container and ship by ground US mail (Federal Express is not necessary) to the above address. For reproductive tracts that are too large to fix whole and ship (e.g. elephants, rhinoceros, etc), representative sections may be cut according to the attached protocol.  

REQUIRED INFORMATION To include:  It is important that you also provide the information requested on the enclosed form so we can include your case in the AZA CAG surveillance program. This valuable data allows us to assess the effects that age and parity, as well as duration and dose of the contraceptive treatment, can have on the lesions.  We will send a pathology report for the tissues you have submitted and will be certain to acknowledge your institution’s contribution in any publication that includes your submission.

      Thank you in advance for sending cases to this surveillance program.  Your involvement will contribute to our understanding of the effects of contraceptives on reproductive health in zoo mammals 

If you have questions, please contact us at or



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